Church of St. Panteleimon (Nerezi) is a small 12th century Byzantine church located in a monastery complex. The church and monastery are dedicated to St. Panteleimon, the patron saint of physicians. The church was constructed in 1164 as a foundation of Alexius Angelus Comnenus, a son of Constantine Angelos and Theodora Komnene. The church has a domed cruciform core, three apses and a rectangular narthex. It is built of irregular stone blocks and brick embedded in thick layers of mortar. The surrounding monastery complex is enclosed by walls. The frescoes in the church are famous examples of Comnenian Age Byzantine Art. The coloring, dramatic composition and purity of expression displayed in the frescoes are outstanding examples of Macedonian medieval monumental painting in the later 12th century. 
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